Nutsche Filters & Filter Dryers Steam sterilizable

Pressofiltro® Series PF 50 - PF 6000 Steam sterilizable design

Steam sterilizable COMBER Pressofiltro® agitated Nutsche filter dryers are designed to maintain full sterility during the entire process, from inerting through slurry feeding through filtration, washing and drying until and including the discharging of the dry product.

CIP and SIP provide a very effective, safe and convenient form of sterilization, easy to automate and validate. COMBER Pressofiltro® steam sterilizable agitated Nutsche filter-dryers are increasingly being used for biotechnological and pharmaceutical filtration and drying tasks in aseptic environments. 

Steam sterilizable filter-dryers allow for full validated sterility during the filtration and drying process in production lines for API‘s, intermediates and fine chemicals.

 

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Inerting

Prior to feeding slurry into the agitated Nutsche filter or filter dryer the vessel interior is inerted by a controlled displacement of the oxygen containing atmosphere with Nitrogen. This procedure prevents the potential formation of an explosive atmosphere in the vessel interior.

The washing liquid is evenly distributed over the entire filter cake surface using a wash ring with spray nozzles. By again pressurizing the vessel interior the washing liquid is forced thru the filter cake, displacing any remaining mother liquor and is discharged the same way as the mother liquor during the filtration.


In the reslurry washing process the washing liquid is added to the vessel and mixed with the filter cake using the agitator. By again pressurizing the vessel interior the washing liquid is forced thru the filter cake, displacing any remaining mother liquor and is discharged the same way as the mother liquor during the filtration.

Technical data

Special properties for the customer’s benefit:

  • Additional sensors and control system to find out when the sterilization process finishes
  • validatable stream sterilisation
  • all components flanges, seals and valves in aseptic design
  • calculation, design and manufacture in compliance with Pressure Equipment Directive 97/23/EG or/and ASME U-stamp as well as with cGMP and FDA guidelines
  • EG type examination certification 03ATEX0246X in accord with PED 94/9/EG or with UL-approved electrical components for operations in class 1, division 1 or 2, group C & D environment
  • double mechanical seal, externally interchangeable, non contacting gas-lubricated (lift-off), dry running contact (contacting sliding surfaces) or liquid-lubricated seal
  • sampler valve
  • hydraulic pre-piping made of stainless steal, pre-wiring on terminal box made of stainless steal
  • integral and automatic CIP- / SIP- systems (cleaning and sterilisation in place)


Options:

  • additional heating with microwaves to reduce the drying process
  • sterile versions, removal of the residual layer, isolators (glove box), DQ, IQ, OQ qualification
  • autonomic PLC control or connected to PMSX, heavy current box

Technical data

Dryer
type
 
Internal
Ø
mm
Filter area

 
Nominal volume
l
 
Cake volume
max.
l
Speed
max.
1/min
Drive
kw
PF 50   0.10 50 18 55 2.2
PF 100 500 0.20 100 32 50 4.0
PF 200 640 0.32 230 80 74 4.0
PF 250 700 0.38 280 115 70 5.5
PF 350 800 0.50 400 150 60 5.5
PF 500 S 875 0.60 500 180 52 7.5
PF 500 955 0.70 640 210 46 7.5
PF 750 1050 0.85 770 340 40 7.5
PF 1000 S 1150 1.00 930 415 40 11.0
PF 1000 1270 1.26 1140 505 37 11.0
PF 1500 1380 1.50 1500 750 30 15.0
PF 2000 1600 2.00 2000 1000 30 18.5
PF 2500 1800 2.50 2500 1250 25 18.5
PF 3000 1960 3.00 3000 1500 25 22
PF 4000 2260 4.00 4000 2000 21 22
PF 5000 2535 5.00 5000 2500 18 30
PF 6000 2765 6.00 6000 3000 17 30
Fields of application